Hippocampal Sclerosis

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Hippocampal sclerosis: an inflammatory hypothesis.

2007;69;1204-1205 Neurology Andrew J. Cole Hippocampal sclerosis: An inflammatory hypothesis This information is current as of September 18, 2007 http://www.neurology.org/cgi/content/full/69/12/1204 located on the World Wide Web at: The online version of this article, along with updated information and services, is All rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X. since 1951, ...

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Hippocampus, hippocampal sclerosis and epilepsy.

Hippocampal sclerosis (HS) is considered one of the major pathogenic factors of drug-resistant temporal lobe epilepsy. HS is characterized by selective loss of pyramidal neurons - especially of sectors CA1 and CA3 of the hippocampus - pathological proliferation of interneuron networks, and severe glia reaction. These changes occur in the course of long-term and complex epileptogenesis. The auth...

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Hippocampal Sclerosis: Causes and Prevention.

Hippocampal sclerosis is the commonest cause of drug-resistant epilepsy in adults, and is associated with alterations to structures and networks beyond the hippocampus.In addition to being a cause of epilepsy, the hippocampus is vulnerable to damage from seizure activity. In particular, prolonged seizures (status epilepticus) can result in hippocampal sclerosis. The hippocampus is also vulnerab...

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Cytoarchitectural abnormalities in hippocampal sclerosis.

Hippocampal sclerosis (HS) is the most common pathological substrate for temporal lobe epilepsy with a characteristic pattern of loss of principle neurons primarily in CA1 and hilar subfields. Other cytoarchitectural abnormalities have been identified in human HS specimens, including dispersion of dentate granule cells and cytoskeletal abnormalities in residual hilar cells. The incidence of the...

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Incidental detection of hippocampal sclerosis.

The MR examination of medial temporal structures has recently been pushed to the limits of current technology, with some hope of uncovering the secrets of intractable epilepsy. The specific MR imaging features of one important source of seizures, mesial temporal sclerosis, have been well described. These include a small hippocampus with abnormal signal on T2-weighted scans, but many other findi...

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ژورنال

عنوان ژورنال: Epilepsia

سال: 2004

ISSN: 0013-9580,1528-1167

DOI: 10.1111/j.0013-9580.2004.14604.x